Resuscitating RGCs

Evidence from animal models suggests IOP elevation can induce reduced RGC function that can recover
RGC can be injured but survive
Old animals recover less well
Injured RGC can be rescued

Evidence of functional recovery in humans remains controversial
Multiple studies suggest focal recovery after glaucoma surgery
Learning effect does not seem to be only explanation
Mechanism of ongoing recovery over prolonged period not understood

Clinical trials of neuroprotective strategies should be designed to look for evidence of “neuroenhancement”

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