New frontiers in glaucoma

In this stimulating session, top glaucoma researchers provide us their perception about the future of glaucoma care: the role of artificial intelligence, OCT evolution, neuroprotection therapy, genomics and role of autoimmunity. Of note, this session brings us some quite interesting discussions moderated by Dr. Peng Khaw and Dr. Janet Serle.

Deep learning to empower glaucoma docs in the future

Dr. Naama Hammel is a glaucoma specialist who participates in a Google team researching how to apply machine learning in medical data. Dr. Hammel presents a nice introduction on artificial intelligence concepts, how they work, and the great potential of deep machine learning in helping us in the future, although the caveats of accurate labeling of glaucoma images need to be tackled.

OCT in glaucoma: a look into the future

Dr. Lucy Shen presents her perceptions on how OCT may evolve, and discusses some interesting points related to wide-field RNFL map that include both peripapillary and macular region data in a single scan; the improvements in incorporating adaptive optics; the potential of the optic nerve head parameters, lamina cribrosa imaging, and OCT angiography data; how to improve structure-function relationship, and the possibility of associating different technologies that may enable the detection of ganglion cell apoptosis.

Resuscitating RGCs

Dr. Keith Martin presents some of his very interesting research work in retinal ganglion cells and starts by stating that there might be not only healthy or dead retinal ganglion cells, but somehow sick ganglion cells that may be recoverable. Interesting points are presented on the evidence of the location where neuron damage first occurs, the presence of viable ganglion cells that have lost their axons, the relevance in enhancing axonal transport, and what are the possible factors involved in visual function improvement observed particularly after acute IOP reduction.

Personalised glaucoma management: the role of genomics

Dr. Anthony Khawaja provides us a great lecture and discussion on how genomics may improve the precision of glaucoma care. As more data become available, genetic profile testing may allow us to detect individuals at higher risk for glaucoma due to genetical susceptibility for abnormalities in key places like Schlemm canal or optic nerve head. It may also eventually help predict response to treatments. All this genetic profiling would permit us to provide individualized glaucoma precision management and improve patient care with a more appropriate allocation of resources.

The role of autoimmunity and glaucoma therapy

Dr. Franz Grus finishes the session presenting the current research involving antibodies as biomarkers for glaucoma, its potential for identifying some antibodies that may be associated with a more aggressive course of the disease, and eventually its role in developing new therapeutic approaches. Although also limited by proper labeling of true glaucomatous disease, the antibody profile testing also has the potential to collaborate for a better-individualized assessment related to all steps of glaucoma care.

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Please note that no separate slide decks are available with these presentations. 

The Many Faces of Dreaded Bleb Complications

Trabeculectomy remains our well-known reference standard surgery for uncontrolled glaucoma, however, this surgery may present some complications that requires our best management. In this course, experienced glaucoma surgeons discuss their preferred approaches for preventing and treating some of the most dreaded bleb complications.

The dysesthetic bleb

Dr. Ramanjit Sihota describes the morphological characteristics of a dysesthetic bleb, and its respective symptoms. Many relevant points in the management of the dysesthetic bleb were then discussed, such as timing for intervention (prevention vs. treatment), and surgical approaches for some individualized cases, mainly involving epithelium peeling and conjunctival advancement.

The encapsulated bleb

Dr. Eugenio A Maul presents the pathogenesis, risk factors, prevention, and management of encapsulated blebs. Prevention should mainly consider diffuse conjunctival/tenon dissection, wide mitomycin-C application, identification of related risk factors and, titration of the wound healing process, particularly while the encapsulation process is occurring. And management may vary from conservative medical therapy to needling procedures with adjunct antimetabolites agent.

The infected bleb
Dr. Fabian Lerner tackled one of the dreaded TRAB complications: blebitis and endophthalmitis, which may occur in around 1-2% of the eyes up to 5 years after TRAB with MMC. Dr. Lerner emphasize the relevant points for pro-actively preventing, as well as recognizing the signs and symptoms of bleb infection, including the “white on red” bleb appearance. The available treatment protocols and visual prognosis were also discussed.

The leaking bleb
Dr. Jody Piltz Seymour discusses all the clinical implications of bleb leakage, from early wound leak that may increase the risk for bleb failure, to chronic late leakage that may present as oozing/sweating blebs, which may lead to infection. Proper use of intraoperative mitomycin-C, wound closure, and pro-active prevention of bleb encapsulation may prevent a leaking bleb. Different treatment strategies that may be used were critically discussed.

The overfiltering bleb

Dr. Esther Hoffmann discusses the most appropriate timing for intervention on overfiltering blebs, which should rely not specifically on IOP values but mainly on functional or anatomical abnormalities. Treatments aims are to raise the IOP to restore normal morphology and best vision while not losing the TRAB efficiency in controlling glaucoma. Transconjunctival sutures seems a good alternative to reduce aqueous flow through an overfiltering flap, and Dr. Hoffman provides us with some good advice about this technique.

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Please note that no separate slide decks are available with these presentations. 

Spotlight on Glaucoma in Africa

As of 2016, the total population of Africa is estimated at 1.225 billion, representing 17% of the world’s population. According to UN estimates, the population of Africa may reach 2.5 billion by 2050 (about 26% of the world’s total) and nearly 4.5 billion by 2100 (about 40% of the world’s total). Only 1.3% of the world’s health workers care for people who experience 25% of the global disease burden, making severe imbalance in health care system in Africa. Africa is the poorest region in the world: 50% of the population lives on less than 1 $/ day. Millions of people don’t have access to health care in general and less than 25% currently have regular access to eye care services. In such a context and gloomy poverty, the prime concern for many is survival, and seeking health care is a decision of last resort. In this “Spotlight in Africa in Africa”, various speakers have given an outline about glaucoma-related issues in the African continent.

Kgaogelo Legodi discusses the visual impairment statistics in the African continent. In Africa, glaucoma accounts for 15% of blindness and it is the region with the highest prevalence of blindness relative to other regions worldwide. He discusses about LEGACY project which is aimed to improve the health care facility in Africa.  Olusola Olawoye discusses the magnitude and burden of the glaucoma problem in Africa. The prevalence of glaucoma in East, Central, and Southern Africa can be conservatively estimated to be 10,000 people for every 1 million population. This prevalence may be higher in West Africa. The annual incidence of glaucoma can be conservatively estimated to be 400 new cases for every 1 million population. Glaucoma is the second leading cause of blindness after cataract, responsible for up to 30% of blindness. With such high prevalence and blindness, the case detection of glaucoma must be carried out at both the primary and secondary levels. Glaucoma and glaucoma-related blindness are more common in the African origin population compared to the Caucasian population. Blindness due to glaucoma has been found to be four to five times more common among people of African descent (PAD) compared with people of European descent. Glaucoma affects over 4% of the PAD adult population, compared with 2% in those of European ancestry (and 16% in subjects over 70 years compared with 6%). Susie Williams discusses the difference in glaucoma manifestation in African populations compared to other populations. She mentioned that POAG is the most common type of glaucoma; more severe disease with poor prognosis compared to other populations. Dan Kiage discusses Challenges and Opportunities of Medical and Surgical Management. He mentioned that “Glaucoma management remains a major challenge in Africa due to the high prevalence of the disease, poverty, a shortage of ophthalmologists, and insufficient infrastructure.”  Trabeculectomy has remained the primary surgical approach due to its markedly low cost and high efficacy. The use of drainage devices is hampered by their cost. One promising low-cost alternative is the non valved Aurolab Aqueous Drainage Implant (Aurolab), but this device has not yet been introduced in Africa. Tony Realini discussed the role of Selective Laser Trabeculoplasty in the African Population. The use of selective laser trabeculoplasty (SLT) is growing in Africa, and the initial reports are encouraging. Several studies are underway to determine the indications and efficacy of SLT in this setting and in the future, we will have cleat guideline about using SLT in this kind of setting. In my opinion, even if the SLT lasers can be accessed and maintained, we still face the challenge of whether the procedure will be singularly effective in the majority of relatively young glaucoma patients who present late and with very high IOP.  Philip Phatudi discussed “My journey – reducing blindness from glaucoma in South Africa”.

Essentially, there are 5 main Challenges related to early detection, diagnosis, and management of glaucoma in the Middle East-Africa region:

1. Adequate Infrastructure: Need to ensure that training institutions, tertiary eye units, and all high-volume eye units are accordingly equipped
2. Affordability & availability of Anti-Glaucoma Drugs: Need to set a national strategy for their procurement and distribution
3. Availability of skilled personnel: Need to Identify, support, re-train and recruit personnel. Identify & support training institutions and the deployment of eye care teams from primary to tertiary levels
4. Patients continuous education Need to develop a culturally sensitive IEC strategy -Target patients at risk
5. The need for National Glaucoma Guidelines/Policies

This would require at least 2 actions:

1. Update the glaucoma strategy section in existing national plans
2. Set up an HRD sub-group to oversee their development and implementation

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The glaucoma surgery armamentarium – what’s in our 2019 bag of tricks

In “The glaucoma surgery armamentarium – what’s in our 2019 bag of tricks” session various internationally renowned glaucoma specialist talks about trick and tips about various glaucoma surgeries from “Gold Standard” Trabeculectomy to newer MIGS.

Mark Walland in “Keep it simple: phaco alone” talks about the role of phacoemcification in glaucoma management. He explains the biological plausibility of cataract extraction, especially in PACD (Primarybangle Closure Disease) patients. Earlier removal of cataracts seems to be a reasonable option in PACD, but at the present time there is no published data to guide the use of clear lens extraction for this condition. We have combined data from trials addressing cataract extraction in PACD and estimates of the rate of the events we hope to prevent with lens extraction to provide guidelines for the use of CLE. In APAC, once the attack has been aborted, clear lens extraction can be considered when conventional treatment does not stabilize the eye following an acute attack. Acute intervention with lens extraction as primary treatment in APAC remains less appealing except in resistant cases due to potential for surgical complications that can be avoided by conventional treatment and an elective approach to the lens if later indicated. The role of CLE in fellow eyes is best restricted to those who continue to have symptoms, or a recurrent attack despite the use of laser iridotomy, laser iridoplasty as well as medications. In PACS, there is currently no role for CLE. For PAC, clear lens extraction is only considered if conventional treatment (LPI, iridoplasty and medications) does not control the IOP and a significant portion of the angle can be opened on indentation gonioscopy. There are no data to support combining CLE with goniosynechialysis. Medically controlled PACG without cataract does not require intervention. CLE is considered in uncontrolled PACG despite conventional laser and medical treatment especially if ‘significant’ angle opening is possible on indentation gonioscopy. A decision is still required in PACG as to whether lens extraction should be combined with trabeculectomy or whether trabeculectomy alone is preferred. There are currently only one randomized controlled trials supporting the use of CLE as a treatment for PACG. A benefit from the procedure is biologically plausible and extrapolation from existing randomized trials to a few specific situations may be possible. Any potential benefit must be carefully weighed against the risks of intervention.

Matthew Schlenker talked about various MIGS procedures. He mainly talked about MIGS related to trabecular bypass. Five-year post-surgery data from the COMPASS-XT long-term safety study showed that the CyPass Micro-Stent group experienced statistically significant endothelial cell loss compared to the group who underwent cataract surgery alone. Although MIGS seem efficient in the reduction of the IOP and glaucoma medication and show a good safety profile, this evidence is mainly derived from non-comparative studies and further, good quality RCTs are warranted. Ingeborg Stalmans talks about microshunt “Xen implant”. She described the technique in great detail. A non-randomized 2 year published data showed, mean IOP reduction and medication count reduction from baseline were − 6.2 (4.9) mmHg and − 1.5 (1.4) at month 24 months. The clinical success rate was 67.6% at 12 months and 65.8% at 24 months. Overall, 51.1 (12 months) and 44.7% (24 months) of eyes were medication-free. A significant percentage of patients do require bleb needling.

Dr. Tanuj Dada talks about the “Gold Standard” surgery for glaucoma: trabeculectomy. He talks about Trabeculectomy without MMC, with MMC, and with Ologen implants. He discusses how to improve the success of surgery by identifying the risk factors. He also discussed adding sclerectomy along with trabeculectomy to improve the success rate: however, we do not have long term data of this procedure comparing to trabeculectomy. He showed various studies showing that trabeculectomy MMC has better success rate compared to trabeculectomy with ologen.

Gordana Sunaric-Megevand discussed non-penetrating glaucoma surgeries. Meta-analysis comparing trabeculectomy versus viscocanalostomy showed a much higher success rate with trabeculectomy. At 2 years, the mean intraocular pressure difference was 3.42 mm Hg (1.80, 5.03). Trabeculectomy was found to have a significantly better pressure-lowering outcome (P<0.0001). Relative risk of adverse events such as perforation of Descemet membrane, hypotony, hyphema, shallow anterior chamber, and cataract formation, were found to be 7.72 (2.37, 25.12), 0.29 (0.15, 0.58), 0.50 (0.30, 0.84), 0.19 (0.08, 0.45), and 0.31 (0.15, 0.64), respectively. Viscocanalostomy had a significantly higher relative risk of intraoperative perforation of Descemet membrane, whereas trabeculectomy had significantly more postoperative adverse events (P≤0.008).

Sheng Lim discussed the role of glaucoma drainage devices in management. He discussed the surgical technique, especially how to make needle track if we are doing patch graft less surgery. He discussed the comparative efficacy between AGV versus Baerveldt. The cumulative failure rate at 5 years was 49% in the Ahmed group and 37% in the Baerveldt group (P = .007). High IOP was the most common reason for failure in both groups, and de novo glaucoma surgery was required in 16% of the Ahmed group and 8% of the Baerveldt group (P = .006). Failure owing to hypotony occurred in 0.4% of the Ahmed group and 4.5% of the Baerveldt group (P = .002). Visual outcomes were similar between groups (P = .90). The Baerveldt group had a lower failure rate, a lower rate of de novo glaucoma surgery, and a lower mean IOP on fewer medications than the Ahmed group. Baerveldt implantation carried a higher risk of hypotony. He mentioned that the complication with Baerveldt is higher in NVG (neovascular glaucoma) and in this group of patients, he would use Ahmed glaucoma Valve. PTVT study showed that the cumulative probability of failure in the trabeculectomy group lower than the tube group.

Eugenio J Maul discussed cyclodestructive procedures, a procedure we usually keep as the last option in glaucoma management.

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Glaucoma Australia Patient Symposium

This symposium was anchored by Glaucoma Australia. It explored how patients and Ophthalmologists can be united by their interests in glaucoma. The passion of the glaucoma Australia patient symposium is to improve awareness and ensure early diagnosis of glaucoma in Australia.

Professor Ivan Goldberg in his opening remarks discussed in simple terms how glaucoma affects the optic nerve. Glaucoma is the commonest cause of irreversible blindness worldwide, often progressive, often asymptomatic until later stages and treatment is lifelong but effective. He highlighted the importance of adherence to medications and clinic visits. He also emphasized the importance of patients and their ophthalmologists forming a strong therapeutic alliance towards preventing glaucoma blindness. He concluded his remarks by highlighting the importance of patient-centered approach in glaucoma management.

Lab based research

Professor Paul Healey discussed how research has greatly improved our understanding of glaucoma. He described glaucoma as one of the most highly heritable diseases. Certain genetic variations have been found in high proportion of glaucoma patients but some of these genes have also been found in normal persons who do not have glaucoma. Polygenic risk scores may be important in determining who will develop glaucoma. This score can add up the risks associated with the presence of multiple genes that have been identified in glaucoma patients. He also discussed gene therapy strategies and concluded that the future of genetic therapy is likely pharmaceutical in which treatment can be personalized.

Clinical advances

Professor Simon Skalicky discussed two equally important concepts in caring for glaucoma patients which are monitoring and treatment. Monitoring involves regular intraocular pressure check and tests of the optic nerve head and field of vision, while treatment involves lowering the intraocular pressure with medications, surgery or lasers. He highlighted the important improvements in clinical practice over the years such as a faster, more user friendly visual field testing and an array of available micro-stents. These stents are a great option in patients with stable glaucoma who need cataract surgery. He concluded that there have been several advancements in glaucoma care over the years and it is important for clinicians to bring these improvements to the clinic setting where they can be beneficial to patients.

Glaucoma Australia Patient support

Annie Gibbins discussed the mission of the glaucoma Australia patients support program. She said there were about 10,000 persons in Australia who are blind from glaucoma. About 300,000 have glaucoma but 50% of these (150,000) remain undiagnosed. The patient support group has a mission to reach out to these undiagnosed persons by creating awareness and ensuring early diagnosis by screening for glaucoma.  Studies show that at 12 months of diagnosis, glaucoma patients use their eye drops properly only 36-50% of the time. One of the goals of the patient support group is to ensure that patients use their medications appropriately all the time.

Apps and Aids to assist patients

Grant Wilson works at Vision Australia and he discussed the apps and aids for persons with visual impairment. Vision Australia supports about 25,000 people with visual impairment in Australia. He described several gadgets and cameras, speakers that can be clipped on the arm of glasses or on phones which are very helpful for persons with visual impairment.

He concluded that keeping in touch with Glaucoma Australia and Vision Australia can help in sustaining the independence and confidence of persons with visual impairment.

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Grand Rounds

Bilateral Cystoid Macular Oedema following SLT both eyes

Dr. Pankaj Bankale discussed a patient with primary angle closure glaucoma and cataracts in both eyes with intraocular pressures of 24mmHg and 26 mmHg in the right and left eyes respectively. Patient had bilateral phacoemulsification and after 3 months his intraocular pressures were 18mmHg and 19mmHg in the right and left eyes respectively. He had Selective Laser Trabeculoplasty (SLT) in both eyes. However, two weeks afterwards, he presented with reduced vision and was found to have Cystoid Macular Edema (CME) in both eyes. The patient was given Ranibizumab (Lucentis) and he responded very well with markedly improved vision.

‘A sticky situation’ – vitreous occlusion of tube of a glaucoma drainage implant

Dr Mei Ling-Chen presented a 36 year old aphakic who was pregnant with her 3^rd child and presented with reduced vision of 6/18 in her better eye. She had a past medical history of juvenile idiopathic arthritis and chronic uveitis which led to secondary glaucoma. She had bilateral Baerveldts shunts in 2010 but recently presented with a raised IOP of 36 mmHg in the better eye. On examination she had a peaked pupil, shallow bleb and a CDR of 0.9 and she had vitreous tracking into her tube shunt device. She underwent surgery under general anaesthesia and had anterior vitrectomy with complete removal of the vitreous wick. Patient had good postoperative outcome and achieved a vision of 6/9 in the better eye. Her IOP reduced to 10mmHg at 6 months.

Unusual case of pupillary block sixteen years after phacoemulsification: A diagnostic challenge

Dr. Natasha Gautam Seth presented a 75-year-old female with sudden onset painful right eye, redness and deterioration in vision. She had cataract surgery in the right eye 16 years ago and in the left eye 8 years with good vision post operatively. There was no posterior capsular rent.  Her IOP was 46mmHg in the right eye and she was commenced on anti-glaucoma medications. She had uniformly shallow anterior chambers with fixed mid dilated and poorly reacting pupil. She had a hazy media but the disc was normal. A diagnosis of acute unilateral IOP rise 16 years after phacoemulsification was made in the right eye. This is a rare occurrence after phacoemulsification. Patient had peripheral iridotomy with limited posterior and anterior vitrectomy.  At surgery patient was noted to have zonular dehiscence with leakage of vitreous into the posterior chamber which might have led to angle closure. Post operatively vision improved to 6/9 and her IOP was controlled at 12mmHg.

A case report of secondary angle closure glaucoma with microspherophakia in a young female.

Dr Sunitha Gowda presented a case of secondary angle closure glaucoma with microsherophakia in a young 25-year-old female. The patient presented with gradual painful deterioration of vision in the right eye. She had a visual acuity of hand motion, shallow anterior chamber in both eyes with IOP of 52 mmHg in the right eye and 20 mmHg in the left eye. Gonioscopy revealed a 360 degree synechial angle closure in both eyes. A diagnosis of angle closure glaucoma with microspherophakia was made. She had clear corneal phacoemulsification and trabeculectomy in the right eye and postoperatively her IOP was 12mmHg without adjunct medications.

Case of Acquired Aniridia with raised intraocular pressure and absent retinal circulation

Dr. Kedarisetti Kiran Chandra presented a case of acquired aniridia with raised intraocular pressure and absent retinal circulation in a 23-year-old patient. The patient was diagnosed with glaucoma with high intraocular pressure. Her gonioscopy showed open angles with prominent iris processes in the right eye. In the left eye she had hypoplastic ciliary body with no visible iris tissue.  There was deep cupping and total absence of retinal circulation in the left eye. A diagnosis of acquired aniridia with raised intraocular pressure and absent retinal circulation was made in the left eye.

Unilateral Open Angle Glaucoma in an adult with large corneas

Dr Marc Alfred Mangahas presented a 29-year-old patient with unilateral open angle glaucoma in an adult with bilateral large corneas. He had one-year history of intermittent blurring of vision in both eyes. He also had significant loss of vision in the right eye with IOP of 56 mmHg.  He had RAPD, bilateral phacodenesis and iridodenesis with bilateral open angles. A diagnosis of unilateral open angle glaucoma with bilateral large corneas was made.

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